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This is not a 'rebound effect' but rather a return to baseline physiology once the drug's influence on GLP-1 receptors diminishes

Examples of these drugs include: ethinyl estradiol/norgestimate ethinyl estradiol/levonorgestrel ethinyl estradiol/norethindrone ethinyl estradiol/drospirenone DIURETICS (WATER PILLS) Taking acarbose with certain drugs that cause your body to lose water may lead to your blood sugar level getting too high, resulting in hyperglycemia

The longest Phase 3 result published so far covers 68 weeks

Either way, this is a compound worth following closely

Medical Evaluation Lab testing may be recommended to assess metabolic health, hormone levels, liver and kidney function, and markers of inflammation