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A decrease in the quantity of opioid receptors or a disruption in -opioid receptorG protein coupling reduces the antinociceptive efficacy of morphine in preclinical and clinical models of diabetic neuropathic pain (DNP) [5,6,7,8]
The "GLP-2TZ" label refers to the same 39-amino-acid peptide sequence that activates both GLP-1 and GIP receptors
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