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ApoE2 occurs in roughly 510% of people and is generally associated with a lower risk of coronary artery diseasealthough it may increase the risk of atherosclerosis in certain cases

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For weight-loss-based analyses, baseline weight was defined as the measurement closest to index from 90 days before through 14 days after index, and maximum percent body-weight reduction was calculated from the lowest observed weight recorded from day 15 after index through the 2-year landmark

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