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Mechanisms of action of GIP, GLP-1 and their agonists
A new Cleveland Clinic analysis of nearly 8,000 patients suggests that discontinuing semaglutide and tirzepatide, on average, does not lead to significant weight regain in clinical practice, as many patients later restart the original medication or try an alternative obesity treatment
At the same time, the delivery is moving from weekly injections to daily pills, with better tolerability, reduced cost, and demonstrated cardiovascular benefit on top of weight loss
The locomotion in the 5-min bin was similar between SPF-sham and ABX-SDV, while ABX-sham showed an overall reduction in locomotion (Supplementary Fig
