pioneer trials semaglutide Efficacy and tolerability by exposure in the and Full article: Clinical review of

Nachnani JS, Bulchandani DG, Nookala A, Herndon B, Molteni A, Pandya P, et al

Increased injection frequency at unchanged doses could amplify nausea, vomiting, constipation, abdominal pain, and injection-site reactions

It also increases intramuscular water retention, which can counteract some of the "flat" appearance that comes from glycogen depletion during dieting

26 Oral semaglutide is co-formulated with the absorption enhancer sodium N -(8-[2-hydroxylbenzoyl] amino) caprylate or SNAC. 27 Co-formulation with SNAC helps facilitate semaglutide absorption in the stomach by increasing the local pH, which, in turn, leads to increased drug solubility and protection against proteolytic degradation

I dug into the science, asked my doctor about it, ordered the supplement, and have been taking the yellow capsule ever since