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The net cost comparison depends heavily on bioavailability

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Biochem J 374:120 Takahama M, Akira S, Saitoh T (2018) Autophagy limits activation of the inflammasomes

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Inflammation in atherosclerotic cardiovascular disease

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Implications for employers: This study is consistent with other studies of GLP-1 medications for both diabetes and obesity demonstrating substantial cardiovascular and metabolic benefits of this class of medications

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Cigna (filed 2024, settled October 2025 for approximately $6 million)

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