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While these clinical studies documented only moderate and heterogeneous effects of GLP-1RAs on lean body mass, rodent studies have demonstrated a reduction of visceral adipose tissue and upregulation of browning-related genes in subcutaneous white adipose tissue, which can lead to a stimulation of energy expenditure by upregulated thermogenesis [79, 109, 110]

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The drug could then be swallowed inside intact cells, and the massive cost of purification would disappear
