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Here, we unveil the detrimental effect of a high cholesterol diet on GLP-1R-dependent glucoregulation in vivo , and the improvement in GLP-1R function that a reduction in cholesterol synthesis using simvastatin exerts in pancreatic islets

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These changes created a clinical environment highly susceptible to pharmacologic fluctuations and rapid shifts into iatrogenic thyrotoxicosis

2C to 8C (36F to 46F)

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