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Animal data provides some support for the concept
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This release can be rapid, with a peak at 10 min post-initial glucose stimulus, followed by a sustained release from major insulin granules (approximately 9095%) lasting up to 60 min under normal conditions (15, 31)
While initially developed as a treatment for diabetes, researchers found that patients taking semaglutide experienced significant weight loss as a side effect

doi: 10.1093/ajcn/83.1.89
