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However, these risks were comparable in other instances with tirzepatide and controls (placebo, insulin, and GLP-1RA) in subgroup analyses according to tirzepatide dose (Table 2)

Rare but serious risks include pancreatitis, gallbladder problems, and thyroid C-cell tumors (observed in animal studies, clinical significance in humans unclear)

a composite of CV death, non-fatal stroke and non-fatal myocardial infarction [MI]) in people with type 2 diabetes who have established cardiovascular disease (CVD) secondary prevention), and in those at high risk of CVD primary prevention (Marso et al, 2016a

GLP-1 microdosing means taking a GLP-1 receptor agonist at doses significantly lower than standard FDA-approved protocols

Meanwhile, scientists continue to research new treatment approaches
