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Implementing European-style controls in the U.S

An example is lorlatinib, a third-generation tyrosine kinase inhibitor designed to avoid being a substrate of Pgp transporter

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Analytical green star area (AGSA) In view of the limitations existing in various greenness tools including NEMI, GAPI or AGREE, such as subjectivity in evaluation or lack of an overall score, the Analytical Green Star Area (AGSA) was designed