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In the ACHIEVE-1 phase 3 trial, the oral small-molecule GLP-1 receptor agonist orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks in adults with early type 2 diabetes

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Activation of microglia in the trigeminal nucleus caudalis (TNC) contributes to this progression

Semaglutide injections work best when rotated across approved body areas
