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[DOI] [PMC free article] [PubMed] [Google Scholar] 99.Madsbad S, Dirksen C, Holst JJ

While there isnt a strong causal link between GLP-1 medications and sleep issues, some clinical data show that a small number of semaglutide users (1.7 to 4.7%) experience insomnia

And even without the vagus nerve, you have this bidirectional communication between the gut microbiome and the brain

95% CI [1.181.49]) and mortality (aOR 1.36

Unlike the transient and localized actions of endogenous GLP-1, GLP-1RAs maintain consistent levels across arterial, portal, and venous compartments
