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The global rise in obesity and depression, two highly prevalent and often comorbid disorders has intensified interest in the gutbrain axis as a shared biological link

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Taking semaglutide-based GLP-1 therapy with methotrexate requires careful medical oversight, but many patients successfully combine these medications under professional supervision

Agents in this group include antioxidants (vitamin E), tumor necrosis factor pathway regulators (emricasan, pentoxifylline, ZSP1601), and immune modulators (cenicriviroc, belapectin)

Notably, 77% of adolescents treated with semaglutide achieved at least a 5% reduction in BMI