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Weight loss reduces peripheral estrogen production, normalizes the hypothalamic-pituitary-ovarian axis, and often restores regular ovulation

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Market Restraints Gastrointestinal Adverse Effects and Stringent Regulatory Requirements Restrain Market Expansion GLP-1 receptor agonists are associated with gastrointestinal side effects such as nausea, vomiting, diarrhea, and reduced appetite, particularly during treatment initiation and dose escalation

doi:10.1038/s41366-024-01533-3 22