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This proactive approach ensures the therapy remains effective and minimizes complications

The exogenous drug operates at much higher concentrations than natural incretin hormones, and its six-day half-life means it is active around the clock regardless of when it peaks

During this time, some patients may see a slight reduction in appetite, while weight loss is often modest

Thus, a loss of estradiol post-menopause, may contribute to the development of obesity, and systemic and cerebral insulin resistance ( This review describes the physiological and pathophysiological mechanisms that govern the actions of estradiol on food intake and energy expenditure during the menstrual cycle ( Menstrual cycle and appetite control: Implications for weight regulation The CNS, particularly the hypothalamus, plays a key role in homeostatic feeding

Its mechanism of action mimics a hormone called GLP-1, which regulates blood sugar and appetite