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doi: 10.1016/j.cell.2019.08.031 56 SullivanJMBoreckiAAOleskevichS

Weight loss achieved through caloric restriction is accompanied by marked elevation in circulating ghrelin (145), which increases feeding drive and has therefore been ascribed as a natural defense against weight loss

Incretin-based drug development As mentioned above, endogenous GLP-1 has a very short half-life (1-2 minutes) due to its rapid degradation by DPP4, limiting its utility for treatment as a therapeutic

Savremeni struni i regulatorni izvori pokazuju dve kljune stvari: GLP-1 agonisti mogu biti veoma korisni u leenju dijabetesa tipa 2 i kontroli telesne mase, ali samo kada se koriste uz jasnu indikaciju, struni nadzor i potovanje bezbednosnih smernica