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Eric Xu ORCID: orcid.org/0000-0002-6829-8144 1 Cell Research volume 30 , pages 11401142 (2020) Cite this article 10k Accesses 52 Citations 21 Altmetric Metrics details Subjects Dear Editor, The glucagon-like peptide-1 receptor (GLP-1R) belongs to class B G protein-coupled receptors (GPCRs)

Two people can weigh the same and look and function very differently

This Week in GLP-1: A $149 Pill, Wegovy HD, and Canadian Generic Delays Here's what happened this week in GLP-1 medications and every story matters if you're waiting for more affordable options in Canada

Seek medical advice if fatigue: Persists beyond several months without improvement, despite adequate nutrition and hydration Worsens progressively or becomes debilitating, significantly impairing daily activities or work capacity Is accompanied by severe or persistent gastrointestinal symptoms (intractable nausea, vomiting, diarrhoea, abdominal pain) Occurs alongside signs of dehydration (dark urine, dizziness, reduced urine output, dry mouth) Is associated with symptoms of hypoglycaemia (tremor, sweating, confusion, palpitations), particularly in patients taking concurrent insulin or sulphonylureas Urgent medical attention is required if patients experience: Severe abdominal pain , especially if radiating to the back, which may indicate pancreatitisa rare but serious adverse effect of GLP-1 medications

GLP-1 RA use is associated with a greater but moderate reduction in HbA 1c and lower risk of DKA when compared with SGLT2i therapy