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Relationship with Clinical Phenotype and Metabolic Comorbidities Metabolic comorbidities may influence the clinical presentation of PD, leading to an earlier onset of cognitive impairment, a greater burden of axial symptoms, and a reduced response to dopaminergic medication [62]

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doi: 10.1016/0020-7292(91)90645-l 39 LundmanBAsplundKNorbergA