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These symptoms typically occur during treatment initiation or dose escalation and often improve over time, though they can be severe enough to necessitate discontinuation in some patients

Similarly, comparative and combination-effect data remain underdeveloped, including head-to-head comparisons of GLP-1RAs against other cerebroprotective strategies and evaluations of concomitant medications (notably SGLT2 inhibitors, statins, antihypertensives and antithrombotics) that may modify baseline risk and treatment effect

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