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The difference comes down to how they work and what they target
The difference is the FDA approval and how your insurance classifies the prescription, which can affect coverage significantly

Patients using semaglutide may experience worsening of these symptoms if they have pre-existing GERD

Since DPP4 is found mainly in the meninges and blood vessels, whereas DPP8 and DPP9 are ubiquitously distributed in the brain, it has been hypothesized that NPY is cleaved to the truncated NPY 3-36 in the periphery by soluble DPP4 or membrane-bound DPP4
