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REDEFINE 1 trial demonstrates superior efficacy of coadministered cagrilintide and semaglutide versus monotherapy or placebo.

Take-home message: GLP-1 medicines improve MASH through both systemic metabolic effects and direct, liver-specific mechanisms, with LSECs emerging as a central regulatory hub

Most countries showed significant positive weekly trends in 20212022, although uptrends in search interest varied considerably between countries

In an attempt to compensate for the loss, other pathways are upregulated, e.g., the increased use of ketones produced from fatty acids by astrocytes that are shuttled to neurons
