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Lipotoxicity and Ectopic Fat Deposition When adipose tissues capacity to safely store excess nutrients is exceeded or functionally impaired, free fatty acids (FFAs) flux increases, resulting in ectopic lipid deposition in non-adipose organs such as the liver, pancreas, and skeletal muscle, thereby exacerbating insulin resistance and -cell stress [19]

In our third indication for CAM2029, polycystic liver disease, Phase 2 POSITANO results presented at EASL (European Association for the Study of the Liver) 2026, supported the treatments efficacy and safety in this rare and serious condition

Along with energy intake, ghrelin also affects energy expenditure

Its beneficial effect, which has apparently been modest in the first year, could be subjected histological improvement, thus becoming the starting point in a change in the trajectory of patients

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