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It also slows down how quickly food leaves your stomach so you feel full longer

GLP-1, however, engages the GLP-1R/ERK1/2/HDAC6 axis to modulate downstream transcriptional activity, it lowers intracellular ROS, reduces Akt and ERK1/2 phosphorylation, restores HDAC6 expression, and thereby alleviates endothelial dysfunction and excessive autophagy (Zummo et al., 2017)

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K., Chari, M

The relative contribution of each receptor target (GIPR, GLP-1R, GCGR) to the effects reported in human trials remains a mechanistic priority, because receptor-selective dissection studies in humans have not appeared in the primary literature