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In both trials, there were substantial improvements in AHI and BMI for those allocated to tirzepatide dosed at 10 mg to 15 mg weekly compared with placebo after 52 weeks

[laughs] Tobias: PhD in organic chemistry, worked for Big Science, worked in clinical diagnostic labs

The problem was the side effects associated, particularly with GLP-1, are what we call peak to trough: so the difference between the highest amount of drug and the lowest and then going back up again to the highest caused by this twice-a-day dosingwhich you can imagine someone bouncing around maybe two to three times, the drug at peak, then trough, causes a lot of GI distress

This is precisely where peptides enter the picture

Coppola, S., Nocerino, R., Paparo, L., Bedogni, G., Calignano, A., Di Scala, C., de Giovanni di Santa Severina, A