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Lixisenatide: A New Daily GLP-1 Agonist for Type 2 Diabetes Management

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J., Dmarco, L., Castelao, A

[7] A boxed warning in the US prescribing information cautions that medullary thyroid cancers have been observed in rats treated with liraglutide, but it is "unknown whether liraglutide causes thyroid C-cell tumors, including medullary thyroid carcinoma, in humans, as relevance to humans of such tumors in rodents has not been determined." [7] Thyroid cancer [edit] At exposures eight times greater than those used in humans, liraglutide caused a statistically significant increase in thyroid tumors in rats

doi: 10.1074/jbc.M112.399899