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In late August 2015, the US FDA issued a warning that drugs like sitagliptin, saxagliptin, linagliptin, alogliptin, and other DPP-4 inhibitors could cause joint pain that can be severe and disabling
[46] It achieves this by activating the AMPK and SIRT1 pathways, which in turn upregulates the expression of uncoupling protein 1 (UCP1)
Chae and the team at Denver Center for Bariatric Surgery

Whilst the research into GLP-1 receptor agonists and Parkinson's disease is promising, it remains in relatively early stages, and robust evidence from large-scale trials is needed before these drugs can be recommended for neuroprotection or symptom management in Parkinson's disease

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