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2024;16: e244661

[Accessed on 11 June 2026] Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2) (2025)

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A subgroup analysis of the four trials investigating semaglutide as the intervention reported greater reduction in MACE than in the pooled analysis (HR (95% CI): 0.82(0.760.88))

This stigmatization affects clinical decision-making, as practitioners may view obesity as a behavioral issue rather than a chronic disease requiring prompt pharmacological intervention