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Using a gut-selective dose of sitagliptin, plasma DPP-4 activity was reduced by approximately 25% and plasma GLP-1 levels were increased (Figure 5)

Many common appetite suppressants work by stimulating the brain with substances that activate the central nervous system to decrease hunger

& Silani, V

These three complementary mechanisms act synergistically with exogenous insulin to improve overall glycemic control while mitigating insulin-associated weight gain
