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J Clin Endocrinol Metab 2018

Uncontrolled hypertension despite treatment with two or more antihypertensive medications "Uncontrolled" generally means a systolic blood pressure consistently above 140 or a diastolic above 90 despite ongoing treatment with at least two antihypertensive medications from different drug classes (such as an ACE inhibitor or ARB, a calcium channel blocker, a thiazide diuretic, or a beta-blocker)

Drawing from the platforms Global Collaborative Network, our study accessed information from 135 healthcare organizations (HCOs), representing over 130 million patient records

Individual results vary and a medical provider will determine your specific treatment plan

All clinical and preclinical data underlying the figures and tables are included in the Source Data files, in accordance with Nature Portfolio data availability policies
