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13-15 In real-world practice, the efficacy for weight reduction is often lower, for example, about 8% for individuals with diabetes and 11% for individuals without diabetes at 60 weeks with semaglutide 2.4 mg/d

Clinical trials have focused on one year of use, but some people may stay on it longer, depending on their progress and goals

Some studies have also documented improvements in markers of endothelial dysfunction and oxidative stress, processes intimately linked with vascular inflammation

Suppliers capable of answering these questions help researchers make more informed decisions

The PIONEER 4 trial showed that oral semaglutide was noninferior to liraglutide (another GLP-1 receptor agonist) for HbA1c reduction but superior for weight loss, and superior to placebo for both outcomes