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GLP-1-RA such as liraglutide [4], semaglutide [5], and the dual agonist tirzepatide [6], activating both the GLP1- and the gastric-inhibitory polypeptide receptor (GIP-R), have been shown to significantly reduce body weight, making them a promising therapeutic option for the treatment of obesity

Dado que estos frmacos ralentizan significativamente el vaciamiento gstrico, los pacientes frecuentemente experimentan efectos secundarios gastrointestinales, siendo el estreimiento uno de los ms comunes, reportado en hasta aproximadamente 25% de los usuarios con dosis para prdida de peso, segn las etiquetas de prescripcin de la FDA

We also expand on these findings by showing that KO of CNS GIPR can sensitize the response to GLP-1R agonism and that CNS GIPR is necessary for the maximal weight loss response to mGIPR-Ab/GLP-1

They are predictable, population-level transitions