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Description
, Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes, New England Journal of Medicine 375, no
In practice, clinicians compare the mechanisms of the common GLP-1 drugs and choose one that matches your medical history, preferences, and response over time

For a minority, residual sensitivity persists but becomes their new normal
One theory is that the VTA DA activity during reward collection is related to salience (Schultz, 2016), making the reward more noticeable after semaglutide

Of the two main incretin hormones released with food ingestion, the actions of glucagon-like peptide-1 (GLP-1) have been exploited for therapeutic benefit