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Until the data of the SURPASS-CVOT trial are available, tirzepatide will most likely have a place in the algorithm of T2D therapy for patients with obesity and T2D that have the therapeutic aim to normalize glycemia and decrease body weight
Side Effects: Similar Profile Across Formulations All GLP-1 medications share common side effects: Nausea Vomiting Diarrhea Constipation Abdominal discomfort These gastrointestinal effects are typically most pronounced when starting treatment or increasing doses, and they often improve over time

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This may be of benefit for anyone with MCAS, and clinical trials are looking at the effectiveness of different doses.[ref][ref] ( Related article: MCAS) Immune system modulation: The receptor for GLP-1 is found on the cell membrane of macrophages, regulatory T cells, and natural killer T cells