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Women using oral contraceptives should use an alternative or backup method for 4 weeks after tirzepatide initiation and with each dose increase due to potential reduced contraceptive effectiveness

But the pattern differs between the two medications in ways that matter for dosing decisions

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JAMA Intern Med 184(9):10561064 [DOI] [PMC free article] [PubMed] [Google Scholar] Roh E, Choi KM (2023) Hormonal gutbrain signaling for the treatment of obesity

Keep sets in six to twelve rep range for hypertrophy, include heavy singles occasionally to maintain neural drive
