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Incretins Introduction Type 2 diabetes may result from a variety of conditions including -cell dysfunction, where insulin is not produced, and/or due to insulin resistance, in both cases leading to hyperglycemia, and complications in both small and large blood vessels (Silberstein, 2013)

The results of our analysis confirm the lack of any benefit by DPP-4 inhibitors on cardiorenal outcomes in people with type 2 diabetes [22]

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5.1 Limitations Most of the studies yet performed regarding SID and SIH employed observational designs, and data derived from randomised controlled clinical studies are lacking

These medicines demonstrated superior tolerability profiles owing to their less impact on gastric emptying, resulting in fewer gastrointestinal side effects