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[5] [6] Simultaneously, GLP-1 suppresses glucagon secretion, slows gastric emptying, and sends satiety signals to the brain, helping you feel fuller for longer

structuredDataObject Istanbul , Turkey 12 - 15 May 2026 Presentation schedule and materials Time to sustainable weight reduction thresholds with semaglutide 7.2 mg in adults with obesity: A post hoc analysis of the STEP UP trial Georgia Argyrakopoulou 1

The potential for weight loss is interesting, but I think the most interesting reason to pursue glucagon agonism in a multi-receptor agonist is the possibility that you could alter hepatic liver metabolism and potentially decrease fatty acid accumulation and hypertriglyceridemia.

Tirzepatide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2