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At ObesityWeek in 2019, bimagrumab for obesity made a big splash and then it went quiet

Treatment continuity, patient familiarity, adherence, and cost considerations may favor dose optimization before therapeutic switching

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We finally got the results of a trial of GLP-1s for alcoholism

Cardiovascular Effects Dose-dependent increases in heart rate were observed with retatrutide: Heart rate increases peaked at approximately 24 weeks Gradually declined thereafter while remaining elevated above baseline This pattern is similar to that observed with other GLP-1 receptor agonists[4] The clinical significance of these heart rate changes requires further evaluation in larger and longer-term studies