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Representative Western blot and normalized densitometric analysis ( n = 3/group) show that GLP-1(2836) prevented activation of cleaved caspase-3 in the presence of H 2 O 2 versus controls
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Overall, these findings show that GLP-1R recycling is influenced by persistence of agonist binding within the endosomal compartment, resulting in enhanced insulin-releasing properties of fast-dissociating agonists which maintain an adequate population of cell surface receptors over prolonged periods

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