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The landmark STEP 1 trial extension found that participants who stopped semaglutide after 68 weeks of treatment regained approximately two-thirds of their prior weight loss within one year of discontinuation

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Animal Data Female rats given subcutaneous doses of 0.1, 0.25 and 1.0 mg/kg/day liraglutide beginning 2 weeks before mating through gestation day 17 had estimated systemic exposures 0.8-, 3-, and 11-times the human exposure at the MRHD based on plasma AUC comparison