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Both trials will assess once-weekly VK2735 over 78 weeks, with participants being randomly assigned to 7.5 mg, 12.5 mg or 17.5 mg of the study drug or placebo

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CORALreef HeFH: 59.4% LDL-C reduction in 303 patients with heterozygous familial hypercholesterolemia, a genetic cholesterol disorder

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This is exactly why the retatrutide dosage chart escalates gradually, giving your GI system time to adapt to each new level of GLP-1 stimulation