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Indeed, DPP-IV inhibition suppresses the expression, acquisition, and reinstatement of morphine-induced CPP (Lupina et al., 2020)

They found that treating the mice with GLP-1 agonists normalized the fibrosis-related genes, reprogramming the macrophages that caused the scar tissue buildup

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Depending on your situation, this may mean weight loss medication isnt a good fit, or it may require an adjustment of your current medication dosing

Anderson, MD, MAS, an assistant professor of medicine from the University of Pittsburgh, clinical trials of several GLP-1 receptor agonists like semaglutide (Wegovy/Ozempic, Novo Nordisk) for weight loss included exclusion criteria of chronic medical and psychiatric conditions. However, [FDA] labeling does not restrict these treatments in these populations, they wrote in JAMA Internal Medicine