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Recommendations: Maintain consistent hydration Monitor persistent GI symptoms Replenish electrolytes when clinically indicated Severe or prolonged symptoms require medical review

GLP-1RAs administration reduced feelings of hunger, and it was associated with an increase in functional connectivity of the NTS with the hypothalamus

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Creatine and semaglutide can be combined safely in most people with normal kidney function, but requires intentional hydration (810 glasses daily) and baseline kidney testing