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While short-acting versions like daily injections may better control postprandial glucose levels, they have largely been replaced by long-acting alternatives such as semaglutide (Ozempic and Wegovy) and tirzepatide (Mounjaro and Zepbound), which only require weekly injections

The mean apparent clearance following subcutaneous administration of a single dose of liraglutide is approximately 1.2 L/h with an elimination half-life of approximately 13 hours, making Victoza suitable for once daily administration

Research progress on the GIP/GLP-1 receptor coagonist tirzepatide, a rising star in type 2 diabetes

Effects of glucagon-like peptide-1 receptor agonists on non-alcoholic fatty liver disease and inflammation

Moreover, expression of Srd5a3 and Cyp17a1, which are steroidogenesis-related genes, has been found to be decreased in Ihh single-knockout mice