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The influence of diabetes in the pathogenesis and the clinical course of hepatocellular carcinoma: Recent findings and new perspectives

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They compare patients initiating treatment in a given month to those who initiate 12 months later in a one-year follow-up design and 60 months later in a five-year follow-up design, allowing them to control for underlying time trends and baseline health differences

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The G q -mediated effects include the activation of the ERK1/2 pathway of signal transduction
