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Semaglutide helps override some of these signals, but it can't eliminate the underlying metabolic response entirely

Elevated plasma fatty acid levels, being associated with an increased risk of HF, can give rise to lipotoxicity (81)

But the GLP-1 side effects are also real: Common: nausea, vomiting, diarrhea, and constipation, especially when starting or raising the dose

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This makes hitting daily protein goals harder, yet maintaining muscle mass during weight loss depends on consuming enough protein