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Semaglutide is the active ingredient in two medications you may have heard of: Ozempic and Wegovy, both made by the pharmaceutical company, Novo Nordisk

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Medications that can enhance the activity of insulin (so-called incretin mimetics) can help to overcome insulin resistance caused by SGAs (and potentially by other psychotropic medications) and essentially lead to weight loss through enhanced fuel efficiency. Metformin, typically dosed up to 1,000 mg twice daily with meals, has increasingly become recognized as a first-line strategy to attenuate weight gain and glycemic dysregulation from SGAs via its ability to reduce insulin resistance

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