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Taking into account the considerable reduction in incretin effect (i.e., the secretion of insulin in response to oral glucose ingestion mediated by GLP-1 and glucose-dependent insulinotropic peptideGIP) in patients with T2DM and the significant anti-hyperglycemic action, GLP-1 RAs are strongly recommended in the management of patients with T2DM [13]

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However, the top 20 most statistically significantly regulated brain regions in response to treatment were analysed as previously described 37

"Semaglutide versus placebo in people with obesity-related heart failure with preserved ejection fraction: a pooled analysis of the STEP-HFpEF and STEP-HFpEF DM randomised trials"