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In separate Phase 2 and Phase 3 trials, retatrutide at 12mg produced greater total body weight reduction than semaglutide at 2.4mg across comparable timeframes, with the difference primarily attributable to retatrutides additional glucagon receptor activation

Novo Nordisk has since developed a higher-dose 7.2 mg formulation that pushes results closer to 20.7% in the STEP UP trial, but this version is still making its way through regulatory channels

How Does Tirzepatide Function

Were so confident youll succeed, that if you participate in our Weight Management Program and dont lose at least 10% of your body weight, youll be eligible for a refund

Mechanistically, GLP-1 receptor agonists influence inflammatory signaling pathways