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Parrish et al., 2008), activation of the Janus kinase 2 - signal transducer and activator of transcription 3 (JAK2-STAT3) pathway (de Jonge et al., 2005), inhibition of the inflammasome (Lu et al., 2014), and inhibition of adenylyl cyclase 6 (Tarnawski et al., 2018)

By activating its ubiquitously expressed receptor GLP1R, GLP-1 regulates multiple physiological processes which are summarized in Fig

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These medications arent always accessible to people who may benefit from them: They are expensive (hundreds of dollars each month) and not always covered by insurance